| Active Minds at Duke | Common Interest | All students |
| Admissions Ambassadors | Common Interest | Undergraduate |
| Adopt A Grandparent | Service | Campus residents |
| Adventist Christian Fellowship | Religious | All students |
| Agape Campus Christian Fellowship | Religious | Undergraduate |
| Air Force Reserve Officer Training Corps | Academic | Undergraduate |
| Alpha Delta Pi | Greek | Undergraduate - Women only |
| Alpha Epsilon Pi | Greek | Undergraduate - Men only |
| Alpha Kappa Psi | Academic | Undergraduate |
| Alpha Phi | Greek | Undergraduate - Women only |
| Alpha Phi Alpha Fraternity, Inc. | Greek | Undergraduate - Men only |
| Alpha Phi Omega - Lambda Nu Chapter | Service | Undergraduate |
| Alpha Tau Omega | Greek | Undergraduate - Men only |
| American Institute of Aeronautics and Astronautics | Academic | Open (community welcome) |
| American Medical Association | Academic | Graduate |
| American Medical Student Association Premed Chapter | Academic | All students |
| American Society for Mechanical Engineers | Academic | Open (community welcome) |
| American Society of Civil Engineers | Academic | All students |
| Amnesty International | Political/Activist | Campus residents |
| Arts and Engagement Project | Arts | All students |
| Arts Theme House | Residential | Undergraduate |
| ArtsConnect | Service | Undergraduate |
| Asian Students Association | Cultural | Undergraduate |
| Association For Computing Machinery | Academic | All students |
| Association for India's Development | Philanthropy | Open (community welcome) |
| Association for India's Development | Service | Open (community welcome) |
| alpha Kappa Delta Phi | Greek | Undergraduate - Women only |
| Bench and Bar Pre-Law Society | Academic | Undergraduate |
| Best Buddies College - Duke Chapter | Service | Undergraduate |
| Big Brothers Big Sisters at Duke | Philanthropy | Undergraduate |
| Biology Majors Union | Academic | Undergraduate |
| Biomedical Engineering Society | Academic | All students |
| Black Male Outreach and Education | Service | All students |
| Black Student Alliance | Cultural | Undergraduate |
| Blue Devils United | Cultural | Undergraduate |
| Brownstone | Residential | All students |
| Buddhist Community at Duke | Religious | Open (community welcome) |
| Bulgarian Association at Duke | Cultural | All students |
| C.A.R.E. for Carter | Service | Undergraduate |
| Cable 13 - Duke Community Television | Media | All students |
| Cambridge Christian Fellowship | Religious | Campus residents |
| Camp Kesem North Carolina | Service | Undergraduate |
| Campus Concert Series | Performing | All students |
| Campus Council | Governance | Undergraduate |
| Campus Crusade for Christ | Religious | Undergraduate |
| Careers in Internal Medicine Interest Group | Common Interest | All students |
| Carpe Noctem Quarterly | Publication | Undergraduate |
| Center for Race Relations | Cultural | Undergraduate |
| Central Campus Council | Residential | Undergraduate |
| CHANCE | Academic | All students |
| Chabad Student Group | Religious | All students |
| Chi Omega | Greek | Undergraduate - Women only |
| Chi Psi Fraternity | Greek | Men only |
| Circle K International | Service | All students |
| Class of 2009 Council | Governance | Undergraduate |
| Class of 2010 Council | Governance | All students |
| Class of 2011 Council | Governance | Undergraduate |
| Club Baseball | Sports (club) | Men only |
| Club Field Hockey | Sports (club) | All students |
| Club Golf | Sports (club) | All students |
| Coffeehouse | Arts | All students |
| College Connection | Academic | All students |
| Collegiate Student Interest Group in Neurology | Academic | Undergraduate |
| Craven Quad Council | Residential | Undergraduate |
| Crazies Who Care | Philanthropy | All students |
| Critical Theory and Cultural Studies Society (Lit Majors Union) | Common Interest | All students |
| Crowell Quad Council | Residential | Undergraduate |
| Cuban American Student Association | Cultural | All students |
| DanceSlam | Performing | All students |
| Defining Movement Dance Group | Performing | Undergraduate |
| Deja Blue | Performing | Undergraduate - Women only |
| DeltAIDS | Philanthropy | All students |
| Delta Delta Delta | Greek | Undergraduate - Women only |
| Delta Gamma | Greek | Women only |
| Delta Kappa Epsilon | Greek | Undergraduate - Men only |
| Delta Sigma Phi | Greek | Undergraduate - Men only |
| Delta Sigma Theta Sorority, Inc. | Greek | Undergraduate - Women only |
| Delta Tau Delta (DTD) | Greek | Undergraduate - Men only |
| Discover Worlds | Service | All students |
| Doctor of Physical Therapy | Academic | Graduate |
| DUU Freewater Presentations | Media | All students |
| DUU Joe College Day | Performing | Undergraduate |
| DUU Major Attractions | Arts | All students |
| DUU Special Projects | Common Interest | All students |
| Duke ACLU | Political/Activist | All students |
| Duke Africa | Cultural | Campus residents |
| Duke Africans in Medicine (AIM) | Common Interest | Graduate |
| Duke Against War | Political/Activist | Open (community welcome) |
| Duke American Grand Strategy Program | Academic | All students |
| Duke Anime | Common Interest | Open (community welcome) |
| Duke Apiary Club | Common Interest | All students |
| Duke Arab Student Organization | Cultural | All students |
| Duke Archery | Sports (recreational) | All students |
| Duke Association for Business Oriented Women | Common Interest | Undergraduate |
| Duke Association for Greater Gaming Education and Recreation | Common Interest | All students |
| Duke Autism Foundation | Philanthropy | Undergraduate |
| Duke Bass Fishing Team | Sports (recreational) | All students |
| Duke Blackjack Team | Cultural | All students |
| Duke Bridge Club | Common Interest | Open (community welcome) |
| Duke Bureau of Carolina Week | Publication | All students |
| Duke Carolina Student Basketball Marathon | Philanthropy | All students |
| Duke Chamber Players | Performing | Undergraduate |
| Duke Chapel Choir | Performing | Open (community welcome) |
| Duke Chapel Pathways | Religious | All students |
| Duke Cheerleading | Sports (varsity) | Women only |
| Duke Chemistry Major's Union | Academic | All students |
| Duke China Care | Service | All students |
| Duke Chinese Dance Troupe | Arts | All students |
| Duke Chinese Student Association | Cultural | Undergraduate |
| Duke Chinese Students and Scholars Association | Cultural | Graduate |
| Duke Chorale | Performing | Open (community welcome) |
| Duke Circus | Common Interest | Open (community welcome) |
| Duke Club Ice Hockey | Sports (club) | All students |
| Duke Club Ski & Snowboard Team | Sports (club) | All students |
| Duke Club Softball | Sports (club) | Women only |
| Duke Club Swimming | Sports (club) | All students |
| Duke Club Wrestling | Sports (club) | All students |
| Duke College Bowl | Academic | All students |
| Duke College Mentors | Service | All students |
| Duke College Republicans | Political/Activist | All students |
| Duke Community Garden | Common Interest | Open (community welcome) |
| Duke Conservative Union | Academic | All students |
| Duke Consulting Club | Common Interest | Undergraduate |
| Duke Conversations | Academic | (not specified) |
| Duke Cycling Club | Sports (club) | All students |
| Duke Dance Marathon | Philanthropy | All students |
| Duke Debate | Academic | All students |
| Duke Democrats | Political/Activist | All students |
| Duke Dhamaka | Cultural | All students |
| Duke East Asia Nexus | Academic | All students |
| Duke Ethiopian Student Transnational Association | Cultural | All students |
| Duke Family Medicine Interest Group | Academic | All students |
| Duke Fashion Magazine | Publication | All students |
| Duke Friends of Israel | Cultural | Open (community welcome) |
| Duke German Club | Cultural | All students |
| Duke Global Medical Brigades | Service | All students |
| Duke Gymnastics | Sports (recreational) | All students |
| Duke Habitat for Humanity | Service | Open (community welcome) |
| Duke Hillel | Religious | All students |
| Duke Human Rights Coalition | Political/Activist | Undergraduate |
| Duke Innovative Design Agency | Arts | Undergraduate |
| Duke Innoworks | Service | All students |
| Duke International Relations Association | Academic | All students |
| Duke InterVarsity Christian Fellowship | Religious | Undergraduate |
| Duke Investment Club | Common Interest | Undergraduate |
| Duke Journal of Public Affairs | Publication | All students |
| Duke Karate | Sports (recreational) | Open (community welcome) |
| Duke Kendo | Sports (recreational) | All students |
| Duke Lasya | Performing | All students |
| Duke Latter-day Saint Student Association | Religious | All students |
| Duke Manna Christian Fellowship | Religious | Undergraduate |
| Duke Marketing Club | Common Interest | Undergraduate |
| Duke Martial Arts Club | Sports (club) | All students |
| Duke Men's Club Basketball | Sports (club) | All students |
| Duke Men's Club Volleyball | Sports (club) | Men only |
| Duke Microfinance Leadership Initiative | Academic | All students |
| Duke Mock Trial | Academic | Undergraduate |
| Duke Moot Court | Common Interest | Undergraduate |
| Duke Net Impact Undergrad | Academic | Undergraduate |
| Duke Newman Catholic Student Center | Religious | Undergraduate |
| Duke Orthodox Christian Student Association | Religious | Open (community welcome) |
| Duke Outing Club | Sports (club) | Open (community welcome) |
| Duke Partnership for Service | Service | Undergraduate |
| Duke Persian Students Association | Cultural | All students |
| Duke Political Science Students Association | Academic | Undergraduate |
| Duke Political Union | Political/Activist | (not specified) |
| Duke Pre-vet Society | Academic | Undergraduate |
| Duke Prevent Blindness | Service | Undergraduate |
| Duke Psychology Majors Union | Academic | Undergraduate |
| Duke Public Speaking Club | Academic | Undergraduate |
| Duke pre-Dental Society | Academic | Undergraduate |
| Duke Raas | Sports (club) | All students |
| Duke Real Estate Club | Common Interest | All students |
| Duke Red Cross | Service | All students |
| Duke Refugee Aid | Service | Undergraduate |
| Duke Relay For Life | Philanthropy | Open (community welcome) |
| Duke Robotics | Academic | All students |
| Duke SALAM | Political/Activist | All students |
| Duke Section of the National Council of Negro Women | Common Interest | Open (community welcome) |
| Duke Smart Home | Academic | All students |
| Duke South Asian Students Association | Cultural | All students |
| Duke Start-up Challenge | Academic | All students |
| Duke Student Government | Governance | Undergraduate |
| Duke Student Think Tank | Political/Activist | All students |
| Duke Student Veterans Association | Social (open) | Open (community welcome) |
| Duke Students Against Sweatshops | Political/Activist | All students |
| Duke Students for Humane Borders | Service | All students |
| Duke Students for Life | Political/Activist | All students |
| Duke Swing Dancing Club | Common Interest | Open (community welcome) |
| Duke Symphony Orchestra | Performing | Open (community welcome) |
| Duke Tea Club | Common Interest | All students |
| Duke University Athletic Bands | Performing | All students |
| Duke University Badminton Club | Sports (club) | All students |
| Duke University Chinese Student and Scholar Association | Cultural | All students |
| Duke University Club Ice Skating | Sports (club) | All students |
| Duke University Culinary Society | Common Interest | All students |
| Duke University EMS | Service | Open (community welcome) |
| Duke University Equestrian Team | Sports (club) | Undergraduate |
| Duke University Honor Council | Common Interest | All students |
| Duke University Improv | Performing | Undergraduate |
| Duke University Mathematics Union | Academic | Undergraduate |
| Duke University Men's Club Soccer | Sports (club) | Men only |
| Duke University Men's Lacrosse Club | Sports (club) | Men only |
| Duke University Men's Water Polo Club | Sports (club) | All students |
| Duke University Mens Crew | Sports (club) | All students |
| Duke University Naval Reserve Officer Training Corps | Service | Undergraduate |
| Duke University Rugby Football Club | Sports (club) | Undergraduate - Men only |
| Duke University School of Nursing Student Council | Academic | Graduate |
| Duke University Sporting Clays | Sports (recreational) | Undergraduate |
| Duke University Student Dining Advisory Committee | Governance | Undergraduate |
| Duke University Table Tennis | Sports (club) | Undergraduate |
| Duke University Union | Common Interest | All students |
| Duke University Wind Symphony | Performing | Open (community welcome) |
| Duke University Women's Club Soccer | Sports (club) | Women only |
| Duke University Women's Rugby Football Club | Sports (club) | Women only |
| Duke Venture Forward | Common Interest | Undergraduate |
| Duke Violin Tutors | Arts | Undergraduate |
| Duke Wealth Management | Common Interest | Undergraduate |
| Duke Wesley Fellowship | Religious | Open (community welcome) |
| Duke Women's Club Volleyball | Sports (club) | Women only |
| Duke Women's Mentoring Network | Social (open) | All students |
| Duke Women's Ultimate Frisbee Team | Sports (club) | Women only |
| Duke-Durham Hunger Alliance | Service | All students |
| Duke-Durham Tennis Program | Service | Open (community welcome) |
| Duke/Durham Chess Club | Common Interest | Open (community welcome) |
| DukeEngage Student Programming and Advisory Committee | Service | Undergraduate |
| DukeOUT | Cultural | Graduate |
| DukePlayers | Performing | All students |
| Durham Capoeira Cooperative | Sports (recreational) | All students |
| Durham Student Partnerships | Service | Undergraduate |
| East Campus Council | Residential | Undergraduate |
| Economics Student Union | Academic | Undergraduate |
| Edens Quad Council | Residential | Undergraduate |
| Engineering Student Government | Governance | Undergraduate |
| Engineers Without Borders - Duke University Chapter | Service | All students |
| English Majors' Union | Academic | All students |
| Entrepreneurial Latina Leaders in Action | Service | Undergraduate - Women only |
| Environmental Alliance | Political/Activist | Undergraduate |
| EOS/ENV Majors Union | Academic | Undergraduate |
| Eruditio | Publication | Undergraduate |
| Evolutionary Anthropology Majors Union | Academic | Undergraduate |
| Farmhand | Service | All students |
| Fellowship of Christian Athletes | Religious | All students |
| Females Excelling More in Math, Engineering, and Science | Service | Women only |
| Few Quad Council | Residential | Undergraduate |
| Freewater Productions | Media | Open (community welcome) |
| Fuqua Entrepreneurship and Venture Capital Club (EVCC) | Common Interest | All students |
| Future is Now | Service | Undergraduate - Women only |
| Gente Aprendiendo por Nuevas Oportunidades | Service | Undergraduate |
| Global Health Forum | Common Interest | Undergraduate |
| Gothic Guardian | Publication | All students |
| Graduate and Professional Student Council | Governance | Graduate |
| Graduate-DOC | Service | Graduate |
| Haitian Student Alliance | Cultural | Open (community welcome) |
| Healing Expressions | Service | All students |
| Health Arts Network at Duke Students | Service | All students |
| Healthy Devils Peer Educators | Service | Undergraduate |
| Hindu Students Association | Religious | All students |
| Hong Kong Students Association | Cultural | (not specified) |
| Hoof 'n' Horn | Performing | All students |
| Human Revolutionaries for Peace | Religious | All students |
| IMPACT Christian Ministry | Religious | All students |
| Inside Joke | Performing | All students |
| Institute of Electrical and Electronics Engineers - Duke Student Branch | Academic | All students |
| Inter-Greek Council | Greek | All students |
| Interfaith Dialogs Project | Religious | Open (community welcome) |
| Interfraternity Council | Greek | Undergraduate |
| International Association | Cultural | All students |
| International Christian Fellowship | Religious | All students |
| International Justice Mission | Political/Activist | All students |
| Iota Mu Chapter of Alpha Kappa Alpha Sorority, Incorporated | Greek | Undergraduate - Women only |
| Iota Xi Chapter of Kappa Alpha Psi Fraternity, Inc. | Greek | Undergraduate - Men only |
| Italian Speakers Association | Cultural | All students |
| Japanese Association at Duke | Cultural | All students |
| Jazz at the Mary Lou | Cultural | All students |
| John Spencer Bassett Memorial Fund | Publication | Undergraduate |
| JYOTI | Social (open) | Graduate |
| Kappa Alpha Order | Greek | Men only |
| Kappa Alpha Theta | Greek | Undergraduate - Women only |
| Kappa Kappa Gamma | Greek | Women only |
| Karamu Drama Group | Performing | Undergraduate |
| Keohane Quad Council | Residential | Undergraduate |
| Kilgo Quad Council | Residential | Undergraduate |
| Know Your Status | Service | All students |
| Kol Kachol | Performing | All students |
| Korean Undergraduate Student Association | Cultural | Undergraduate |
| Kville | Common Interest | Undergraduate |
| La Unidad Latina, Lambda Upsilon Lambda, INC. | Greek | Men only |
| Lady Blue | Arts | Women only |
| Lambda Phi Epsilon | Greek | Undergraduate - Men only |
| Language Theme House | Social (selective) | Undergraduate |
| Latent Image | Publication | Undergraduate |
| Leadership Roundtable | Leadership Program | Undergraduate |
| Learning Through Experience, Action, Partnership, and Service | Service | Open (community welcome) |
| Les Diables Blues | Cultural | Open (community welcome) |
| LifeDesign | Common Interest | Graduate |
| Linkademy, Inc. | Duke Student Ventures (Certification Required) | Open (community welcome) |
| Live Entertainment/Broadway | Arts | Undergraduate |
| Living Policy Forum | Common Interest | Graduate |
| Lutheran Campus Ministry | Religious | All students |
| Major Speakers | Common Interest | All students |
| Manna Project International - Duke University | Service | All students |
| Maxwell House | Residential | Undergraduate |
| McKids | Service | Undergraduate |
| Men's Club Tennis | Sports (club) | Men only |
| Men's Ultimate | Sports (club) | Men only |
| Mercado Global | Common Interest | All students |
| Mi Gente | Cultural | All students |
| Millennium Villages Project | Philanthropy | All students |
| Minority Association for Pre-Medical Students | Academic | Undergraduate |
| Mirecourt | Residential | Undergraduate |
| Momentum | Arts | All students |
| Muslim Medical Students Association | Religious | All students |
| Muslim Students Association | Religious | All students |
| Nasher Student Advisory Board | Arts | All students |
| National Association for the Advancement of Colored People | Political/Activist | Open (community welcome) |
| National Pan-Hellenic Council | Greek | Undergraduate |
| National Society of Black Engineers | Academic | All students |
| Native American Student Alliance | Cultural | Open (community welcome) |
| Neuroscience Majors' Union | Academic | Undergraduate |
| Nourish International | Philanthropy | All students |
| Nutrition and Dietetics Interest Group | Common Interest | Graduate |
| Omega Phi Beta Sorority, Incorporated | Greek | Undergraduate - Women only |
| Omega Psi Phi Fraternity, Inc. | Greek | Undergraduate - Men only |
| On Tap | Performing | Open (community welcome) |
| One Laptop per Child University Initiative at Duke | Service | All students |
| Operation Smile | Service | All students |
| Operation Snowball | Service | Undergraduate |
| Order of Omega | Greek | Undergraduate |
| Origami Club at Duke University | Arts | All students |
| Out of the Blue | Performing | Undergraduate - Women only |
| Panhellenic Association | Greek | Undergraduate - Women only |
| Partners for Learning | Service | All students |
| Passport Magazine | Publication | Undergraduate |
| PetICare | Service | Undergraduate |
| Phi Beta Sigma Fraternity Incorporated | Greek | Undergraduate - Men only |
| Phi Delta Theta | Greek | Undergraduate - Men only |
| Phi Sigma Pi National Honors Fraternity | Academic | Undergraduate |
| Physics Graduate Student Organization | Governance | Graduate |
| Pi Beta Phi | Greek | Undergraduate - Women only |
| Pi Kappa Alpha | Greek | Men only |
| Pi Kappa Phi | Greek | Undergraduate - Men only |
| PlanV: Duke's Vegetarian Club | Common Interest | Open (community welcome) |
| Policy and Management Interest Group | Academic | Graduate |
| Polygraph | Media | Graduate |
| Precision Step Team | Performing | All students |
| Prism Selective Living Group | Cultural | Undergraduate |
| Progressive Alliance | Political/Activist | Open (community welcome) |
| Progressive Health Partnership | Service | Open (community welcome) |
| Project Child | Philanthropy | Undergraduate |
| Project HEAL: Health Education and Awareness in Latin America | Service | Undergraduate |
| Project WILD | Common Interest | Undergraduate |
| Prospective Health Care Club | Common Interest | Undergraduate |
| Psi Upsilon | Greek | All students |
| Public Policy Major's Union | Academic | Undergraduate |
| Purple | Service | Campus residents |
| Racquetball Club | Sports (club) | Campus residents |
| REMEDY | Service | Open (community welcome) |
| REMEDY@Duke | Service | Open (community welcome) |
| Reformed University Fellowship | Religious | All students |
| Religio | Publication | Undergraduate |
| Rhythm and Blue | Performing | Undergraduate |
| RIVAL Magazine | Media | All students |
| Rince Diabhul: Irish Dance and Culture Club | Performing | All students |
| Roadrunners Running Club | Sports (club) | All students |
| Round Table | Social (selective) | Undergraduate |
| Russian Majors and Minors Association | Academic | Open (community welcome) |
| Sabrosura | Performing | All students |
| Sanford MPP Social Committee | Social (selective) | Graduate |
| Sapphire A cappella | Arts | Women only |
| ScienceDays | Service | All students |
| Scott House | Residential | (not specified) |
| Selective Living Groups | Residential | Campus residents |
| Self Knowledge Symposium | Religious | All students |
| Sierra Leone Educational Enrichment Project at Duke | Political/Activist | Open (community welcome) |
| Sigma Chi Fraternity | Greek | Undergraduate - Men only |
| Sigma Gamma Rho Sorority Incorporated | Greek | Undergraduate - Women only |
| Sigma Nu | Greek | Undergraduate - Men only |
| Sigma Phi Epsilon Fraternity | Greek | Undergraduate - Men only |
| Singapore Student Association | Social (open) | All students |
| Small Town Records | Media | All students |
| Social Entrepreneurship and Enterprise Development for Students | Common Interest | Undergraduate |
| Society of American Foresters | Common Interest | Graduate |
| Society of Automotive Engineers | Academic | Open (community welcome) |
| Society of Duke Fellows | Academic | Graduate |
| Society of Hispanic Professional Engineers | Academic | All students |
| Society of Women Engineers | Academic | Undergraduate |
| Something Borrowed Something Blue | Performing | All students |
| Speak of the Devil | Performing | Men only |
| Splash Duke | Service | All students |
| Sports Club Council | Sports (club) | All students |
| Step Up | Leadership Program | Open (community welcome) |
| Stop Motion Crew | Common Interest | Open (community welcome) |
| Student Housing for Academic and Residential Experimentation | Residential | Undergraduate |
| Student Interest Group in Neurology and Neurosurgery | Academic | Graduate |
| Student Mentoring & Academic Reinforcement Tutoring Progam | Philanthropy | All students |
| Student National Medical Association | Service | Graduate |
| Student Organization Finance Committee | Governance | Undergraduate |
| Students for Choice | Political/Activist | All students |
| Students for the Ethical Treatment of Animals | Political/Activist | Open (community welcome) |
| Students of the Caribbean Association | Cultural | Undergraduate |
| Students of the World | Service | All students |
| Students Taking an Active Role in Sustainability | Academic | All students |
| Taiwanese Student Association | Cultural | All students |
| Tau Beta Pi | Academic | All students |
| Teaching and Mentoring Interest Group | Service | Open (community welcome) |
| Team HBV | Service | All students |
| Thai Student Organization | Cultural | All students |
| The Archive | Publication | Undergraduate |
| The Chanticleer | Publication | All students |
| The Chronicle | Publication | All students |
| The Dancing Devils | Sports (club) | Undergraduate |
| The Duke Baha'i Club | Religious | Open (community welcome) |
| The Duke Entrepreneur | Common Interest | Undergraduate |
| The Duke Organ Donation Initiative | Service | All students |
| The Dukes of Comedy | Performing | Undergraduate |
| The Girls Club | Service | Undergraduate - Women only |
| The Inferno | Sports (recreational) | All students |
| The Navigators | Religious | All students |
| The Nicholas Naturalists | Common Interest | Graduate |
| The Pitchforks | Performing | Undergraduate - Men only |
| Theta Nu Xi Multicultural Sorority, Inc. | Greek | Undergraduate |
| Towerview Magazine | Publication | All students |
| Toys and Tales | Service | All students |
| Triathlon Club | Sports (recreational) | Open (community welcome) |
| Turkish Students Association | Cultural | All students |
| Ubuntu | Residential | Undergraduate |
| Undergraduate Publications Board | Governance | Undergraduate |
| United in Praise | Performing | Undergraduate |
| Universitas Scholarium | Academic | All students |
| Universities Allied for Essential Medicines | Political/Activist | All students |
| Vertices, Duke University Journal of Science and Technology | Publication | Undergraduate |
| Vietnamese Student Association | Cultural | All students |
| Vision for North Korea | Cultural | All students |
| Visual Arts Committee | Arts | All students |
| VoraciTee | Philanthropy | All students |
| Wayne Manor | Social (selective) | Undergraduate - Men only |
| Wendell Theater Group | Performing | All students |
| Westminster Fellowship at Duke | Religious | Undergraduate |
| Wilderness Outdoor Opportunities For Durham Students | Academic | All students |
| Wired2Achieve | Service | All students |
| Women's Club Basketball | Sports (club) | Undergraduate - Women only |
| Women's Club Lacrosse | Sports (club) | Women only |
| Women's Club Tennis | Sports (club) | Women only |
| Women's Institute for Secondary Education and Research @ DUKE | Common Interest | Open (community welcome) |
| WXDU | Media | Open (community welcome) |
| You are What You Eat Nutrition Education Program | Service | Graduate |
| Zeta Phi Beta Sorority, Incorporated | Greek | Women only |
| Zeta Tau Alpha | Greek | Women only |
